Here, we show that BMP9/Alk1 signaling inhibits neovessel formation in mouse models of pathological ocular angiogenesis relevant to AMD. BMP9 signaling through the endothelial Alk1 serine-threonine kinase receptor modulates the response of endothelial cells to VEGF and promotes vessel quiescence and maturation during development. The drawbacks of inhibitors of vascular endothelial growth factor (VEGFs) currently used for the treatment of AMD, which include resistance and potential serious side-effects, require the identification of new therapeutic targets to modulate angiogenesis. Received: ApAccepted: JPublished: AugAbstractĪge-related macular degeneration (AMD) is the leading cause of blindness in aging populations of industrialized countries. Keywords: age-related macular degeneration, ocular pathologies, angiogenesis, BMP signaling, Gerotarget Paul Oh 5, Anne Eichmann 6,7 and Bruno Larrivée 1,3,4,8ġ Department of Biomedical Sciences, Maisonneuve-Rosemont Hospital Research Center, University of Montreal, Montreal, Quebec, CanadaĢ Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Center, University of Montreal, Montreal, Quebec, Canadaģ Department of Molecular Biology, Maisonneuve-Rosemont Hospital Research Center, University of Montreal, Montreal, Quebec, CanadaĤ Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Center, University of Montreal, Montreal, Quebec, Canadaĥ Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, USAĦ Yale Cardiovascular Research Center, New Haven, CT, USAħ Inserm U970, Paris Cardiovascular Research Center, Paris, FranceĨ Department of Biological Sciences, Université du Québec à Montréal, Montréal, Quebec, Canada
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